USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: DEST_HUMAN USC-OGP 2-DE database:  DEST_HUMAN DEST_HUMAN General information about the entry View entry in simple text format Entry name DEST_HUMAN Primary accession number P60981 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Destrin; AltName: Full=Actin-depolymerizing factor; Short=ADF;. Gene name Name=DSTN Synonyms=ACTDP, DSN Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0580: pI=6.28; Mw=17978 SPOT OGP-0583: pI=5.87; Mw=17844 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1062: pI=6.31; Mw=18056 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1327: pI=6.59; Mw=17706 SPOT OGP-1352: pI=8.49; Mw=13705 Cross-references UniProtKB/Swiss-Prot P60981; DEST_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DEST_HUMAN Primary accession number P60981 Secondary accession number(s) B2R6N2 B4DYA6 P18282 Q5W166 Q6IAW2 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 135) Name and origin of the protein Description RecName: Full=Destrin; AltName: Full=Actin-depolymerizing factor; Short=ADF; Gene name Name=DSTN Synonyms=ACTDP, DSN Encoded on Name=DSTN; Synonyms=ACTDP, DSN Keywords Acetylation; Actin-binding; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL S65738; AAB28361.1; -; mRNA EMBL CR457042; CAG33323.1; -; mRNA EMBL AK302338; BAG63668.1; -; mRNA EMBL AK312645; BAG35529.1; -; mRNA EMBL AL132765; CAC10585.1; -; Genomic_DNA EMBL CH471133; EAX10274.1; -; Genomic_DNA EMBL CH471133; EAX10275.1; -; Genomic_DNA EMBL CH471133; EAX10276.1; -; Genomic_DNA EMBL BC009477; AAH09477.1; -; mRNA CCDS CCDS13127.1; -. [P60981-1]; . CCDS CCDS46580.1; -. [P60981-2]; . PIR A54184; A54184; . RefSeq NP_001011546.1; NM_001011546.1. [P60981-2]; . RefSeq NP_006861.1; NM_006870.3. [P60981-1]; . RefSeq XP_011527444.1; XM_011529142.1. [P60981-1]; . RefSeq XP_011527445.1; XM_011529143.1. [P60981-1]; . RefSeq XP_011527446.1; XM_011529144.1. [P60981-2]; . UniGene Hs.304192; -; . UniGene Hs.705996; -; . ProteinModelPortal P60981; -; . SMR P60981; -; . BioGrid 116223; 94; . IntAct P60981; 16; . MINT MINT-5001125; -; . STRING 9606.ENSP00000246069; -; . DrugBank DB04147; Lauryl Dimethylamine-N-Oxide; . iPTMnet P60981; -; . PhosphoSitePlus P60981; -; . SwissPalm P60981; -; . BioMuta DSTN; -; . DMDM 46577586; -; . OGP P18282; -; . REPRODUCTION-2DPAGE IPI00473014; -; . UCD-2DPAGE P60981; -; . EPD P60981; -; . PaxDb P60981; -; . PeptideAtlas P60981; -; . PRIDE P60981; -; . DNASU 11034; -; . Ensembl ENST00000246069; ENSP00000246069; ENSG00000125868. [P60981-1]; . Ensembl ENST00000474024; ENSP00000476975; ENSG00000125868. [P60981-2]; . GeneID 11034; -; . KEGG hsa:11034; -; . UCSC uc002wpq.4; human. [P60981-1]; . CTD 11034; -; . DisGeNET 11034; -; . GeneCards DSTN; -; . HGNC HGNC:15750; DSTN; . HPA CAB037094; -; . MIM 609114; gene; . neXtProt NX_P60981; -; . OpenTargets ENSG00000125868; -; . PharmGKB PA27509; -; . eggNOG KOG1735; Eukaryota; . eggNOG ENOG41122P5; LUCA; . GeneTree ENSGT00440000033289; -; . HOGENOM HOG000039697; -; . HOVERGEN HBG000381; -; . InParanoid P60981; -; . KO K10363; -; . OMA WIPDTIQ; -; . OrthoDB EOG091G0PWC; -; . PhylomeDB P60981; -; . TreeFam TF328601; -; . SIGNOR P60981; -; . ChiTaRS DSTN; human; . GenomeRNAi 11034; -; . PRO PR:P60981; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000125868; -; . CleanEx HS_DSTN; -; . ExpressionAtlas P60981; baseline and differential; . Genevisible P60981; HS; . GO GO:0015629; C:actin cytoskeleton; TAS:ProtInc; . GO GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0030042; P:actin filament depolymerization; IDA:UniProtKB; . GO GO:0030043; P:actin filament fragmentation; IEA:Ensembl; . GO GO:0051014; P:actin filament severing; TAS:ProtInc; . GO GO:0008154; P:actin polymerization or depolymerization; TAS:ProtInc; . GO GO:0030836; P:positive regulation of actin filament depolymerization; IEA:Ensembl; . CDD cd11286; ADF_cofilin_like; 1; . Gene3D 3.40.20.10; -; 1; . InterPro IPR002108; ADF-H; . InterPro IPR029006; ADF-H/Gelsolin-like_dom; . InterPro IPR017904; ADF/Cofilin; . InterPro IPR029924; Dstn; . PANTHER PTHR11913; PTHR11913; 1; . PANTHER PTHR11913:SF39; PTHR11913:SF39; 1; . Pfam PF00241; Cofilin_ADF; 1; . PRINTS PR00006; COFILIN; . SMART SM00102; ADF; 1; . PROSITE PS51263; ADF_H; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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